Cisplatin included platinum coordination complex is known that it causes drug interaction with furosemide, NSAIDs, antihistamines, phenothiazines, ciprofloxacin, aminoglycosides, etc. Cisplatin is inevitably used with other drugs because of its chemotherapeutical characteristics. Therefore, we reviewed the charts of 24 hospitalized patients administered cisplatin, at St. Mary´s Hospital from March 1. 1998 to March 31. 1998. This survey is an investigation about the apearance of interactions between cisplatin and other drugs which are known to interact with cisplatin.
Fourteen kinds of drugs were coadministered with cisplatin. NSAIDs was used to nine patients, furosemide to twenty four, antihistamine and phenothiazine to seven, ciprofloxacin to four, and sodium thiosulfate to four patients. As a result, four patients used NSAIDs had nephrotoxicity and we didn´t find toxicities from the other patients.
We concluded an effective monitoring is needed to reduce the adverse effect caused by drug interactions and to provide a right information to medical staff.
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